causation, ComplexTraits, GWAS, JournalClub, MultiOmics
Detecting variants shared between traits, detecting potential causality from GWAS summary data
Pickrell et al. (Pickrell et al., 2016) come up with a very nice approach which uses summary-level data to detect variants exhibiting effects on multiple traits. They also propose use of multi-locus information to infer causative relations between traits. The manuscript starts with reminding the reader that the observed association between a genetic variant and multiple […]
Read full case study