ComplexTraits, genomics, GWAS, Omics, pain

Genomic approach to determine psychological and anatomic determinants of back pain

Back pain is the number one cause of years lived with disability worldwide and one of the most common reasons for health care visits in developed countries, yet surprisingly little is known regarding the biology underlying this symptom. In our previous study1, published in Sept 2018, we identified three novel genetic variants associated with chronic […]

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genomics, metabolomics, Omics, pleiotropy, QTL, statistics

Different pleiotropic scenarios determine joint distribution of human metabolite levels

Adding covariates can either increase or decrease the power of finding an effect of a predictor on the outcome of interest. In a recent publication in GigaScience we used knowledge of biochemical networks to select covariates for conditional genetic association analysis. We demonstrated that the power depends on whether genes and environment play along or […]

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ComplexTraits, GWAS, Omics, pain

New Genetic Variants Associated with Chronic Back Pain

Back pain is the #1 cause of years lived with disability worldwide and one of the most common reasons for health care visits in developed countries, yet surprisingly little is known regarding the biology underlying this symptom. A new study, led by Pradeep Suri of the Department of Veterans Affairs in Seattle, Washington (U.S.A.) and […]

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glycomics, Omics, pain

Chronic inflammation and low back pain

Last Thursday, July 5, 2018, a manuscript1 reporting results from a large multicentric case-control study of patients with chronic lower back pain (CLBP) was published in Biochimica et Biophysica Acta (BBA) – General Subjects. The work was funded by the EU FP7 project PainOmics in which we participate. The study of plasma N-glycome composition in patients […]

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ComplexTraits, eQTL, genomics, GWAS, Omics, transcriptomics

Identification of sixty three multigenic modules involved in susceptibility to inflammatory bowel disease

Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Crohn’s disease (CD) and ulcerative colitis (UC) are the principal types of inflammatory bowel disease. IBD was virtually unheard of in the early nineteen hundreds. Since then it’s incidence (as well as that of a series of other inflammatory diseases including asthma) has dramatically […]

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education, genetics, genomics, Omics, teaching, training

Massive open online course “From Disease to Genes and Back” is open

In PolyOmica, we some times need to train people in the basics of genetics and genomics. While training people in basics is fun, it is quite time consuming, and is not exactly our company’s core activity. For a long time, we thought that it would be great to have a massive open online course (MOOC) […]

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conference, genomics, MIMOmics, MultiOmics, Omics, RSSSO, science, summer school, teaching, training

Teaching at the Research MIMOmics Summer School in Cambridge (UK)

From 20 till 27 August, the EU FP7 consortium MIMOmics in which PolyOmica is a partner, organises a Summer School including a Workshop in Omics Studies. The goal of the School is to train a new generation of statistical omics scientists with a biological and biotechnological background to enable them to understand and to apply […]

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conference, MIMOmics, MultiOmics, Omics, science, statistics

Packing for the 4th annual MIMOmics meeting in Zagreb

We are currently preparing for a visit to Zagreb, Croatia, where we will attend the fourth annual meeting of the MIMOmics EU project on which we collaborate. The programme will covers topics like glycomics and metabolomics, statistical prediction based on multiple omics, casual inference, networks and epidemiology. So if you are in the vicinity of […]

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MIMOmics, Omics, RSSSO, summer school, teaching, training

The 2016 Research Summer School in Statistical Omics

We have just returned from Split, Croatia, where we organised and co-sponsored the third Research School in Statistical Omics (RSSSO2016). With this Summer School we aim to train young researchers (at bachelor, master or PhD level) with a bio{logical,medical,chemical} background and interest in quantitative statistical methods to become the next generation of life scientists; these […]

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ComplexTraits, eQTL, genomics, GWAS, JournalClub, MultiOmics, Omics, transcriptomics

Integration of summary data from GWAS and eQTL studies

In this work, Zhu and colleagues [1] start with asking the question whether it would be possible to use summary-level data coming from GWAS of a complex trait coupled with eQTL association results to address the question of causality. Could the association observed for the complex trait be explained by changes in the level of a […]

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JournalClub, microbiome, Omics

Revised estimates for the number of human and bacteria cells in the body

With interest we read a review/analysis paper [1] which questions the ‘common knowledge’ that we have ten times more bacteria on/in us than we we have cells. The authors make an interesting historical analysis tracing the ’10:1′ statement back to its origins (back to the beginning of 1970s!); based on analysis of more recent literature, they […]

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Tag: Omics

ComplexTraits, genomics, GWAS, Omics, pain

genomics, metabolomics, Omics, pleiotropy, QTL, statistics

ComplexTraits, GWAS, Omics, pain

glycomics, Omics, pain

ComplexTraits, eQTL, genomics, GWAS, Omics, transcriptomics

education, genetics, genomics, Omics, teaching, training

conference, genomics, MIMOmics, MultiOmics, Omics, RSSSO, science, summer school, teaching, training

conference, MIMOmics, MultiOmics, Omics, science, statistics

MIMOmics, Omics, RSSSO, summer school, teaching, training

ComplexTraits, eQTL, genomics, GWAS, JournalClub, MultiOmics, Omics, transcriptomics

JournalClub, microbiome, Omics

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